Work Package 1

WP1: Development of drug delivery systems
PI Thomas Andresen,
Department of Micro- and Nanotechnology, Technical University of Denmark

We are focused on developing innovative new solutions for transporting macromolecules into the brain and studying their distribution. Particularly we are focused on:

  • Research in nanocarrier systems for targeting the blood brain barrier
  • Research in nanocarrier systems that are sensitive to the microenvironment inside the brain endothelial cells or brain interstitium, obtaining target specific drug release
  • Development of new regiospecific conjugation chemistries for antibodies
  • Synthesis of new drug delivery carrier materials
  • Synthesis of new reporter molecules for investigating biodistribution and transport of macromolecules and nanocarriers in brain
  • Novel gene delivery systems for obtaining gene silencing or expression in brain endothelium
  • Understanding the role of protein adsorption to nanocarriers in relation to their biodistribution and pharmacokinetics
  • Characterization of nanocarrier systems in biological systems by electron microscopy
  • Investigating the role of glycocalyx in nanocarrier transport by electron microscopy
  • Optimization of pathological models for testing nanocarrier systems, including brain cancer.

 

Participants:

Kasper Kristensen, PhD
Position: PostDoc
Email: kakri@nanotech.dtu.dk

Martin Bak
Position: PhD student
Email: marba@nanotech.dtu.dk

Mette Aagaard Lund
Position: PhD student
Email: metlun@nanotech.dtu.dk

Paul Kempen, PhD
Position: PostDoc
Email: pkem@nanotech.dtu.dk

Casper Hempel, PhD
Position: PostDoc
Email: cash@nanotech.dtu.dk

Sara Björk Sigurdardóttir
Position: PhD student
Email: sabsi@nanotech.dtu.dk

Matthias Fach, PhD
Position: PostDoc
Email: mfac@nanotech.dtu.dk