Drug delivery to the central nervous system (CNS) is a tremendous challenge for academia and industry. The need for new treatments of brain diseases is growing with the increasing lifespan of western populations. Drug transport across the brain endothelium forming the blood-brain barrier (BBB) is a particularly great challenge because of the low intrinsic permeability of the barrier to most solutes and the presence of active efflux transporters.
Our multidisciplinary research program combines investigation of drug transport systems with investigation of BBB function and the neurovascular unit (NVU), the cells closely associated with the brain endothelium. The aim of the Research Initiative is to provide the new tools necessary to design novel drug delivery systems for transport of drugs across the BBB. This Research Initiative started its activities in March 2014 and consists of five primary investigators (PIs).
The research at the Research Initiative on “Drug delivery to the brain and blood-brain barrier transport mechanisms” encompasses five specific work packages (WP):
WP1: Development of drug delivery systems, PI Thomas Andresen, DTU
WP2: In vitro investigations of brain endothelial cell receptor internalization and trafficking pathways, PI Morten S. Nielsen, AU,
WP3: In vivo monitoring of nanocarrier transport and therapy in the brain, PI Torben Moos, AAU
WP4: Signalling at the NVU and BBB control, PI Martin Lauritzen, KU
WP5: In vitro models of the neurovascular unit, PI Birger Brodin, KU
PhD defense: Sofie Hørlyck
Dec 11, 2017
Sofie Hørlyck will defend her PhD thesis...
8th RIBBDD biannual meeting
Nov 14, 2017
On October 23-24th 2017, the 8th RIBBDD biannual meeting took place...
Portrait of young scientists
Sep 29, 2017
New series of portraits of our talented young scientists...
Sep 20, 2017
Professor Torben Moos (WP3) has participated in the radio program ”Brinkmann på P1” ...
Sep 01, 2017
New publications from the RIBBDD network...
There are no upcoming events at this time.
All RIBBDD members are highly encourage to actively participate in external events to broader their knowledge