Drug delivery to the central nervous system (CNS) is a tremendous challenge for academia and industry. The need for new treatments of brain diseases is growing with the increasing lifespan of western populations. Drug transport across the brain endothelium forming the blood-brain barrier (BBB) is a particularly great challenge because of the low intrinsic permeability of the barrier to most solutes and the presence of active efflux transporters.
Our multidisciplinary research program combines investigation of drug transport systems with investigation of BBB function and the neurovascular unit (NVU), the cells closely associated with the brain endothelium. The aim of the Research Initiative is to provide the new tools necessary to design novel drug delivery systems for transport of drugs across the BBB. This Research Initiative started its activities in March 2014 and consists of five primary investigators (PIs).
The research at the Research Initiative on “Drug delivery to the brain and blood-brain barrier transport mechanisms” encompasses five specific work packages (WP):
WP1: Development of drug delivery systems, PI Thomas Andresen, DTU
WP2: In vitro investigations of brain endothelial cell receptor internalization and trafficking pathways, PI Morten S. Nielsen, AU,
WP3: In vivo monitoring of nanocarrier transport and therapy in the brain, PI Torben Moos, AAU
WP4: Signalling at the NVU and BBB control, PI Martin Lauritzen, KU
WP5: In vitro models of the neurovascular unit, PI Birger Brodin, KU
Extended funding for RIBBDD
Mar 10, 2017
The Lundbeck Foundation awards further DKK 20 million to the Research Initiative on Br...
Professor Martin Lauritzen receives the Niels A. Lassen Award
Dec 15, 2016
The prize is awarded for his research in brain blood flow and disease mechan...
Interview and new publication
Nov 08, 2016
An interview with RIBBDD PI Birger Brodin have been published in the Scientist
RIBBDD biannual meeting
Oct 07, 2016
On September 12-13th 2016, the second RIBBDD biannual meeting took place. The meeting was held in the Faculty Club at Faculty of Health and Medical Scie...
There are no upcoming events at this time.